During the first 6 months of legislatively mandated premarital testing for human immunodeficiency virus in Illinois, 8 of 70 846 applicants for marriage licenses were found to be seropositive, yielding a seroprevalence of 0.011%. The total cost of the testing program for 6 months is estimated at $2.5 million or $312 000 per seropositive individual identified. Half of the reported seropositive individuals reported a history of risk behavior. During the same period, the number of marriage licenses issued in Illinois decreased by 22.5%, while the number of licenses issued to Illinois residents in surrounding states increased significantly. We conclude that mandatory premarital testing is not a cost-effective method for the control of human immunodeficiency virus infection.
Turnock BJ, Kelly CJ. Mandatory Premarital Testing for Human Immunodeficiency VirusThe Illinois Experience. JAMA. 1989;261(23):3415–3418. doi:10.1001/jama.1989.03420230069028