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Article
August 17, 1994

Safety and Side Effects of Sustained-Release Niacin

Author Affiliations

University of Minnesota Minneapolis

JAMA. 1994;272(7):513. doi:10.1001/jama.1994.03520070031015
Abstract

To the Editor.  —The study by Dr McKenney and colleagues1 is described by the authors as a "well-designed clinical trial." We would concur with that description if the authors would make more explicit the intention of the study, namely, that it was clearly designed to maximize the potential for niacin intolerance and toxicity. Despite their obvious familiarity with the clinical literature, they chose a peculiarly unphysiologic twice-daily dosing schedule. Similarly, they intentionally escalated both the immediate-release (IR) nicotinic acid and sustained-release (SR) nicotinic acid to a total dose of 3000 mg (1500 mg twice daily), whether or not the patient had demonstrated an adequate lipid response at a lower dose.

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