[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.128.52. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 6, 1989

RU-486 as an Antiprogesterone SteroidFrom Receptor to Contragestion and Beyond

Author Affiliations

From the Lab Hormones, Institut National de la Santé et de la Recherche Médicale and Faculté de Médecine, Bicêtre, France.; Dr Baulieu is a consultant to Roussel-Uclaf, the manufacturer of RU-486.

From the Lab Hormones, Institut National de la Santé et de la Recherche Médicale and Faculté de Médecine, Bicêtre, France.; Dr Baulieu is a consultant to Roussel-Uclaf, the manufacturer of RU-486.

JAMA. 1989;262(13):1808-1814. doi:10.1001/jama.1989.03430130084039
Abstract

The steroid RU-486 (mifepristone) is an antiprogesterone that works at the receptor level. It can interrupt pregnancy very early on (contragestion), mostly by interfering with the process of implantation and decidua function. It also may facilitate surgical evacuation of the uterus and certain difficult deliveries. It impedes ovulation when taken during the follicular phase. Also, RU-486 is the first antiglucocorticosteroid available for clinical use. It deserves further studies to assess its wide range of therapeutic potential.

(JAMA. 1989;262:1808-1814)

×