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October 6, 1989

Long-term Complications of Therapy for Cancer in Childhood and Adolescence

Author Affiliations

University of Illinois College of Medicine at Chicago

University of Illinois College of Medicine at Chicago

JAMA. 1989;262(13):1863-1864. doi:10.1001/jama.1989.03430130139052

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


In a little over two decades, childhood cancer has been transformed from nearly certain death into a chronic disease. Accompanying the successful cure of malignancy have emerged the sequelae—what I call the "iatrogenic disease of success." Because onset of the sequelae may occur years later, their recognition and management, so important to optimizing the quality of the patient's survival, require knowledge on the part of the internists, pediatricians, and family practitioners who will be caring for our survivors. Pediatric oncology protocols are now attempting to reduce the long-term complications while maintaining and improving the survival rates.

The author draws upon the vast experience of the Roswell Park Memorial Institute; reviews the extensive literature, including individual case reports; and synthesizes the current knowledge into a very readable format.

The monograph is organized by organ systems and is replete with well-organized tables and graphs, to put this problem into a succinct perspective.