Since circulating fibronectin levels have been associated with trauma, the relationship between fibronectin and fasting was investigated. Eighteen healthy but obese patients fasted for 21 days, and plasma fibronectin levels were determined weekly. Fibronectin concentrations were reduced throughout the fast, but increased after food intake. This starvation-induced decrease in fibronectin may be a deleterious mechanism associated with physiological insults.
Scott RL, Sohmer PR, MacDonald MG. The Effect of Starvation and Repletion on Plasma Fibronectin in Man. JAMA. 1982;248(16):2025-2027. doi:10.1001/jama.1982.03330160073028