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January 19, 1990

Disorders of the Spleen: Pathophysiology and Management

Author Affiliations

The University of Chicago Chicago, Ill

The University of Chicago Chicago, Ill

JAMA. 1990;263(3):462. doi:10.1001/jama.1990.03440030151044

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This beautifully illustrated, wellindexed 450 + -page volume presents a clear and comprehensive, yet concise, review of splenic disorders in adults and children.

It begins with a discussion of normal anatomy and function, then proceeds to a review of gross and microscopic pathology in a variety of splenic disease states. Disturbed splenic function— both hyposplenism and hypersplenism—is discussed in depth. Emphasis is placed on pathophysiologic mechanisms, where known, and available clinical methods (including imaging techniques) for diagnosing the functional state of the spleen. There is detailed attention given to the workup and management of the patient with splenomegaly. Systematic review of neoplastic, storage/metabolic, infectious, and immune disorders is presented. Recommendations for treatment of asplenic individuals are included.

This monograph is commended particularly for successfully relating data from the basic sciences to clinical features of disturbed splenic function. The pathology and relevant basic immunology are included not as a comprehensive review, but