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This monograph is Dr Irvine Page's personal view of the notable accomplishments and individuals in the field of hypertension research, from the beginning of his own career in the 1920s, when hypertension was linked to chronic infection and there was little interest in investigating its pathophysiology, to the 1960s, when the emphasis of hypertension research became pharmacologic therapy and large clinical trials. This is not an objective history but a distinctly personal overview of developments that laid the groundwork for work done in the 1970s and 1980s.
Looking back to the more distant past, Page remarks, "It is an interesting commentary on how little interest was shown in arterial hypertension in the early part of this century that although many observations clearly offered important leads, none of them were followed" (p 44). In the early 1920s, the prevailing theory was that hypertension was hereditary or a manifestation of neurocirculatory asthenia
Barker S, Messerli FH. Hypertension Research: A Memoir 1920-1960. JAMA. 1990;263(8):1151–1152. doi:10.1001/jama.1990.03440080142040