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Article
April 4, 1990

Substituting Diagnostic Services

JAMA. 1990;263(13):1767-1768. doi:10.1001/jama.1990.03440130047023
Abstract

To the Editor.—  Eisenberg et al1 define the blood type and crossmatch and type and screen as "substitutable tests." The type and screen characterizes the red blood cells of a particular patient/potential recipient in terms of the expression of certain major human blood group antigens and tests the same patient's serum for the presence of antibodies to a much larger group of commonly and less commonly expressed red blood cell antigens. The crossmatch, by contrast, assesses the degree of immunologic compatibility between a particular donor unit and a particular potential recipient.For many years, certainly during the study period, the type and crossmatch has included an antibody screen, and the procedure might more accurately be described as a type, screen, and crossmatch. Since pooled screening red blood cells contain a great many more kinds of antigen than are expressed on the cells within an individual donor unit, the

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