[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.159.202.12. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 26, 1994

Early Intervention in Low-Birth-Weight Premature InfantsResults Through Age 5 Years From the Infant Health and Development Program

Author Affiliations

University of Arkansas for Medical Sciences, Little Rock; Albert Einstein College of Medicine, Bronx, NY; Harvard Medical School, Boston, Mass; University of Miami (Fla) School of Medicine, Miami; University of Pennsylvania School of Medicine, Philadelphia, Pa; University of Texas Health Science Center, Dallas; University of Washington School of Medicine, Seattle, Wash; Yale University School of Medicine, New Haven, Conn; The Johns Hopkins University, Baltimore, Md; Albert Einstein College of Medicine, Education Testing Service, Teachers College at Columbia University, and Yale University
From the Center for Children and Families, Teachers College, Columbia University, New York, NY (Dr Brooks-Gunn); Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY (Dr McCarton); the Department of Pediatrics, University of Arkansas for Medical Science, Little Rock (Drs Casey and Swanson); Department of Maternal and Child Health, Harvard University School of Public Health, Boston, Mass (Dr McCormick); the Department of Pediatrics, University of Miami (Fla) School of Medicine (Dr Bauer); Children's Hospital of Philadelphia, University of Pennsylvania (Dr Bernbaum); the Department of Pediatrics, University of Texas Health Science Center, Dallas (Drs Tyson and Swanson); the Department of Pediatrics, University of Washington, Seattle (Drs Bennett and Scott); the Department of Pediatrics, Yale University, New Haven, Conn (Dr Scott); and the Department of Biostatistics, The Johns Hopkins University, Baltimore, Md (Drs Tonascia and Meinert).

JAMA. 1994;272(16):1257-1262. doi:10.1001/jama.1994.03520160041040
Abstract

Objective.  —To evaluate the persistence of effects on health and development at age 5 years of the Infant Health and Development Program, an early childhood intervention that was provided to low-birth-weight (LBW) premature infants from neonatal discharge through age 3 years.

Design.  —Randomized, controlled, multicenter trial, stratified by two LBW groups: lighter (≤2000 g) and heavier (2001 to 2500 g).

Setting.  —Eight socioeconomically heterogeneous clinical sites.

Participants.  —Of 985 eligible infants weighing 2500 g or less and at 37 weeks' or less gestational age, 377 infants were randomly assigned to the intervention group and 608 to the follow-up only group. About two thirds of the infants in each group were in the lighter LBW stratum, and one third were in the heavier LBW stratum.

Intervention.  —The intervention group received home visits (from neonatal discharge through age 3 years) as well as center-based schooling (from 1 to 3 years of age). Children in both groups received pediatric surveillance.

Main Outcome Measures.  —Cognitive development, behavioral competence, and health status.

Results.  —At age 5 years, the intervention group had full-scale IQ scores similar to children in the follow-up only group. However, in the heavier LBW stratum, children in the intervention group had higher full-scale IQ scores (3.7 points higher; P=.03) and higher verbal IQ scores (4.2 points higher; P=.02). No significant differences between intervention and follow-up only groups in cognitive measures at age 5 years were noted in the lighter LBW infants. The intervention and follow-up groups were similar in behavior and health measures regardless of LBW stratum.

Conclusion.  —The early childhood intervention provided in the first 3 years of life had effects on heavier LBW premature infants' IQ and verbal performance at age 5 years that were not observed for lighter LBW premature infants. The intervention did not affect health or behavior at age 5 years in either LBW stratum.(JAMA. 1994;272:1257-1262)

×