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May 16, 1990


JAMA. 1990;263(19):2681-2682. doi:10.1001/jama.1990.03440190137074

Exciting events in diagnostic radiology occurring over the past year include the development of a model of atherosclerosis at the University of Washington (Seattle) Medical Center by Goldman et al1 using Yucatan microswine. The lesions are established by placing the animal on a high-fat diet and using intra-arterial balloons to denude the vascular endothelium. Histopathologic lesions identical to those observed in human atherosclerotic vascular disease may not develop for 5 or more months. The lesions reveal a fibrous cap with intimal hyperplasia, foam cells, necrosis, and calcification. The advantage of producing such lesions in this model is that arteries similar in size to the superficial femoral artery are accessible. This model was developed for the purpose of evaluating angioplasty devices, including various balloons, instruments for atherectomies, and lasers. Effectiveness of therapy, complications, and the occurrence of restenosis may be studied using this model. In addition, it can be used