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May 23, 1990

Gastrointestinal Disorders: A Pathophysiologic Approach

Author Affiliations

University of Chicago (Ill) School of Medicine

University of Chicago (Ill) School of Medicine

JAMA. 1990;263(20):2828. doi:10.1001/jama.1990.03440200134043

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Gastrointestinal Disorders: A Pathophysiologic Approach is meant to teach rather than merely inform. The fourth edition provides a thorough update of the pathogenesis and clinical presentation of gastrointestinal problems.

The author provides recent advances in the mechanism of gastric acid secretion with a clear explanation of the hydrogen/potassium adenosinetriphosphatase proton pump and its inhibitor omeprazole. He compares and contrasts the four available H2-receptor antagonists. There is a review of pancreatic enzyme secretion, toxic and drug-induced hepatitis, and the formation of cholesterol gallstones.

The format of this 400 + -page, singleauthored, paperback monograph, with its liberal use of tables, figures, and graphs to highlight the crisp, carefully edited text, makes it a valuable tool for medical students, house officers, GI fellows, and those who teach gastroenterology. The chapter discussing the differential diagnosis and evaluation of a patient with jaundice is particularly well done. Case presentations are used to develop the