May 23, 1990

Gastrointestinal Disorders: A Pathophysiologic Approach

Author Affiliations

University of Chicago (Ill) School of Medicine

University of Chicago (Ill) School of Medicine


by Norton J. Greenberger, 4th ed (Internal Medicine Series), 438 pp, with illus, paper $39.95 ISBN 0-8151-3928-4, Chicago, III, Year Book Medical Publishers Inc, 1989.

JAMA. 1990;263(20):2828. doi:10.1001/jama.1990.03440200134043

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Gastrointestinal Disorders: A Pathophysiologic Approach is meant to teach rather than merely inform. The fourth edition provides a thorough update of the pathogenesis and clinical presentation of gastrointestinal problems.

The author provides recent advances in the mechanism of gastric acid secretion with a clear explanation of the hydrogen/potassium adenosinetriphosphatase proton pump and its inhibitor omeprazole. He compares and contrasts the four available H2-receptor antagonists. There is a review of pancreatic enzyme secretion, toxic and drug-induced hepatitis, and the formation of cholesterol gallstones.

The format of this 400 + -page, singleauthored, paperback monograph, with its liberal use of tables, figures, and graphs to highlight the crisp, carefully edited text, makes it a valuable tool for medical students, house officers, GI fellows, and those who teach gastroenterology. The chapter discussing the differential diagnosis and evaluation of a patient with jaundice is particularly well done. Case presentations are used to develop the