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Article
July 11, 1990

Intradermal vs Intramuscular Hepatitis B Vaccinations-Reply

Author Affiliations

University of California at Davis Medical Center Sacramento, Calif
Baylor College of Medicine Houston, Tex

University of California at Davis Medical Center Sacramento, Calif
Baylor College of Medicine Houston, Tex

JAMA. 1990;264(2):182. doi:10.1001/jama.1990.03450020033014
Abstract

In Reply.—  We applaud the well-designed study by Wiström et al that demonstrates that low-dose ID inoculation of adults with three 2-μg doses of a recombinant hepatitis B vaccine (Recombivax-HB, Merck Sharp & Dohme) results in lower seroconversion rates and reduced levels of antibody to HBsAg compared with three 10-μg IM injections of the same product.These results are not unexpected. There is a positive correlation between dose and immune response regardless of the type of product used.1 In our ID study we were able to use the more immunogenic plasma-derived Hepta

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