[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
November 16, 1994

Surgeons Try Immune Therapy for Breast Cancer

JAMA. 1994;272(19):1485. doi:10.1001/jama.1994.03520190031022

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


IMMUNE THERAPY may hold promise for preventing metastasis in breast cancer patients, according to new animal studies.

The treatment opens up the possibility of improving survival after primary breast tumors are excised, said H. Kim Lyerly, MD, clinical director of the Molecular Therapeutic Program at Duke University Medical Center, Durham, NC. "It may also increase the utility of surgery for women with metastatic disease because it can prevent further metastases from forming," he added. Lyerly and his colleagues presented their findings in Chicago, Ill, at the annual Clinical Congress of the American College of Surgeons.

The researchers surgically implanted breast cancer tumor cells onto the feet of mice. These cells developed into palpable breast tumors within 7 days of implantation. After 20 days, the researchers removed the tumors. The mice later developed lung metastases in a manner similar to the clinical course of women with breast cancer metastases. Because cytokine

First Page Preview View Large
First page PDF preview
First page PDF preview