November 16, 1994

Hormone Combination Treats Women's Bone Loss

JAMA. 1994;272(19):1487. doi:10.1001/jama.1994.03520190033023

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TWO RECENT investigations of the use of androgen plus estrogen by postmenopausal women have shown that the hormone combination may, according to one study, stimulate bone formation and, per the other, increase bone mineral density. The research was reported at the fifth annual meeting of the North American Menopause Society, held in Washington, DC.

The finding of the study presented by Lawrence G. Raisz, MD, professor and chair, Department of Endocrinology, University of Connecticut School of Medicine, Farmington, if confirmed, is held to be the first in which markers of bone formation were measured in women given an estrogen-androgen combination. The results are of interest because there is no drug approved in the United States as safe and effective that increases bone formation, although drugs are approved for this purpose in many European countries.

The study compared a group of 13 women 50 to 80 years of age treated with

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