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September 12, 1990

Diet and New Lesions of the Coronary Arteries-Reply

Author Affiliations

University of Southern California School of Medicine Los Angeles

University of Southern California School of Medicine Los Angeles

JAMA. 1990;264(10):1252. doi:10.1001/jama.1990.03450100041020

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In Reply.—  Dr Simopoulos indicates the importance of analyzing the results of the Cholesterol Lowering Atherosclerosis Study (CLAS) for the effect of ω-3 and ω-6 fatty acids on new lesion formation. The CLAS data reported in JAMA were based on 24-hour recalls obtained from 1980, when the first subject was randomized, until 1986, when the last subject had a second angiogram. Conversion of recorded foods to nutrient composition was by the University of Minnesota Nutrition Coding Center with Data Tape 10, which did not have complete information on food content of ω-3 and ω-6 fatty acids, and so we did not analyze CLAS data for these fatty acids.During the CLAS we conducted computer-assisted diet counseling based on diet diaries recorded the week before each clinic visit. We stored food intake data from this new method but elected to report results from standardized 24-hour recalls first. We are now analyzing