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—Dr Cocconi and Dr Yun Ryo ask some questions concerning whether the results of the two trials on follow-up of breast cancer can be transferred to clinical practice. The main issue raised by Cocconi relates to the need for continuous reassessment of the frequency of follow-up according to the evolution of medical therapy and assessment of its efficacy based on "tumor burden," while he also agrees that currently it is safe to use conservative follow-up for routine clinical care.However, we strongly believe that the efficacy of any new treatment modality in breast cancer relapses detected early should be assessed in controlled trials before advocating any intensive follow-up regimen.We would like to clarify to Yun Ryo that the study was designed to evaluate the different impact on overall survival of two different follow-up regimens offered to study participants for 5 years. On the other hand, follow-up was
Del Turco MR, Palli D, Cariddi A. Follow-up of Patients With Breast Cancer-Reply. JAMA. 1994;272(21):1659. doi:10.1001/jama.1994.03520210041026