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March 4, 1983

Mitochondrial Creatine Kinase in Cancer Patients

Author Affiliations

Veterans Administration Medical Center Augusta, Ga

JAMA. 1983;249(9):1148. doi:10.1001/jama.1983.03330330030011

To the Editor.—  Mitochondrial creatine kinase (CK-MIT) is an isoenzyme of creatine kinase thought to be of mitochondrial origin that migrates cathodically to the MM fraction on electrophoresis. Bark, in his report entitled "Mitochondrial Creatine Kinase" (1980;243:2058), observed CK-MIT in eight patients, most of whom suffered acute myocardial infarction. All experienced shock with poor tissue perfusion, and six of the eight died within a brief period. He concluded that the presence of CK-MIT indicated severe tissue damage, particularly myocardial, and poor prognosis.We recently detected apparent CK-MIT in two patients without heart disease or shock, both of whom had metastatic carcinoma.

Report of Cases.—Case 1.—  A 63-year-old man complained of low-back pain, night sweats, weakness, and a 12-kg (27-lb) weight loss over several weeks. An examination led to an exploratory laparotomy, at which time multiple nodules were found in the liver. Biopsy findings indicated malignant lymphoma. Although his