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Article
February 20, 1991

Treatable Abdominal Pathologic Conditions and Unsuspected Malignant Neoplasms at Autopsy in Veterans Who Received Mechanical Ventilation

Author Affiliations

From the Department of Medicine, University of California, San Francisco (Drs Papadakis and Mangione); the General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco (Dr Papadakis and Ms Kristof); and the Department of Biostatistics, Veterans Affairs Medical Center, Palo Alto, Calif (Dr Lee). Dr Manigione is now with the Departments of Clinical Epidemiology and General Internal Medicine, Harvard Medical School, Boston, Mass.

From the Department of Medicine, University of California, San Francisco (Drs Papadakis and Mangione); the General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco (Dr Papadakis and Ms Kristof); and the Department of Biostatistics, Veterans Affairs Medical Center, Palo Alto, Calif (Dr Lee). Dr Manigione is now with the Departments of Clinical Epidemiology and General Internal Medicine, Harvard Medical School, Boston, Mass.

JAMA. 1991;265(7):885-887. doi:10.1001/jama.1991.03460070067044
Abstract

Study Objective:  To determine, in medical patients who received mechanical ventilation, the frequency and types of major unexpected diagnoses at autopsy that, if known before death, would probably have led to improved survival (class I errors) or substantively changed management but not survival (class IIB errors).

Design:  Retrospective cohort study.

Setting:  Six medical intensive care units in a Department of Veterans Affairs Cooperative Study.

Patients:  One hundred seventy-two autopsied patients of the 401 veterans who received mechanical ventilation and died in the hospital.

Results:  The class I error rate was 12%. Abdominal pathologic conditions— abscesses, bowel perforations, or infarction—were as frequent as pulmonary emboli as a cause of class I errors. While patients with abdominal pathologic conditions generally complained of abdominal pain, results of examination of the abdomen were considered unremarkable in most patients, and the symptom was not pursued. Six percent of patients had extensive malignant neoplasms (class IIB errors).

Conclusions:  Atypical presentation of potentially treatable abdominal pathologic conditions is a common cause of class I errors in veterans who receive mechanical ventilation. Conversely, several patients with unrecognized terminal conditions underwent intensive intervention. If the information gained at autopsy had been known before death, management would have probably changed substantively in 18% of patients.(JAMA. 1991;265:885-887)

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