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To the Editor.—
Dr Corey, in his scholarly review of the diagnosis and treatment of genital herpes (1982; 248:1041), did not mention erythema multiforme under his list of complications of recurrent genital herpes infection. Erythema multiforme caused by herpes is uncommon, and— in my experience—physicians are usually unaware of this association. Unlike herpes, this complication is treatable; it responds dramatically to corticoids administered for systemic effects. Once the association between recurrent herpes simplex and erythema multiforme is recognized, future misery can be avoided by a one- to two-week course of corticoids administered for systemic effects started at the first sign of erythema multiforme.
Epstein E. Genital Herpes and Erythema Multiforme. JAMA. 1983;249(12):1566. doi:10.1001/jama.1983.03330360020018