[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.159.239.251. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
April 1, 1983

Mismatched marrow grafts succeed thanks to two anti-T-cell agents

JAMA. 1983;249(13):1687-1689. doi:10.1001/jama.1983.03330370003001

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

The A. he patient died, but—the old story—the therapy was a success. Indeed, an Associated Press story heralded the treatment as a major medical break-through. The story, which hit newsstands across the nation on February 15, began hyperbolically, "For the first time, doctors have cured a deadly assault on the body's immune system, saving the life of a week-old baby with an experimental treatment called monoclonal antibodies."

The article was referring to the treatment of Bryan Ahlers, who during surgery to repair a heart defect three days after his birth at Children's Hospital, Buffalo, NY, was given a routine blood transfusion. When rash, fever, diarrhea, and ascites developed, immunologist Byung H. Park, MD, recognized the classic symptoms of graft v host disease (GVHD). This seemed an unlikely response until physicians discovered that Bryan had no thymus. With no mature T lymphocytes of his own, the lymphocytes in the transfused blood

×