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April 1, 1983

Nonoliguric Renal Failure Associated With Zomepirac

Author Affiliations

Stanford University School of Medicine Palo Alto, Calif

JAMA. 1983;249(13):1706-1707. doi:10.1001/jama.1983.03330370020008

To the Editor.—  I would like to report a case of nonoliguric acute renal failure associated with the use of zomepirac sodium.

Report of a Case.—  A 62-year-old man had no history of renal disease but had suffered three prior myocardial infarctions. After his fourth myocardial infarction, a left ventricular aneurysm developed and he was admitted to this hospital for coronary artery bypass as well as aneurysmectomy. After the operation, he suffered a left parietal stroke. His recovery from the stroke was steady, but he became depressed and agitated because of his persisting neurological deficits. He also complained of right shoulder and hip arthralgias. Consequently, a total of four 200-mg doses of zomepirac sodium were given over two days. He concomitantly received small doses of haloperidol and meprotiline. Before receiving the zomepirac sodium, his creatinine level was 1.3 mg/dL; serum urea nitrogen level, 8 mg/ dL. On the second day