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Article
March 27, 1991

Risk Factors for Measles in a Vaccinated Population-Reply

Author Affiliations

Centers for Disease Control Atlanta, Ga
Wisconsin Division of Health Madison

Centers for Disease Control Atlanta, Ga
Wisconsin Division of Health Madison

JAMA. 1991;265(12):1527. doi:10.1001/jama.1991.03460120041022
Abstract

In Reply. —  We thank Dr Waters and Ms Cook for their interest in our report. Our study was designed to assess the independent effects of vaccination before the age of 15 months, time since vaccination, and vaccination before a change in the measles vaccine stabilizer in 1979 as risk factors for measles vaccine failure. Siblings of case patients were selected as controls to attempt to ensure that all case patients and controls were exposed to the measles virus. To investigate age as a risk factor, cases and controls were not age matched because, contrary to the statement by Dr Waters and Ms Cook, the etiologic role of a variable on which both cases and controls are matched cannot be evaluated.1 As Dr Waters and Ms Cook note, case patients in our study were older than the controls. We also agree that crude measles attack rates can vary with

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