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April 1, 1983

Nocturnal Oxygen Desaturation in Patients With Sickle Cell Anemia

Author Affiliations

From the Sleep Disorders Center, University Hospital, the Department of Psychiatry (Drs Scharf and Kramer and Ms De Marchis), and the Department of Medicine (Drs Lobel, Caldwell, and Cameron), University of Cincinnati School of Medicine; and the Cincinnati Comprehensive Sickle Cell Center, Children's Hospital Research Foundation (Drs Lobel, Caldwell, and Cameron and Mr Paine).

JAMA. 1983;249(13):1753-1755. doi:10.1001/jama.1983.03330370063035

The sleep of two patients with sickle cell disease was punctuated by periods with notably reduced arterial O2 saturation despite simultaneous normal respiratory rates. The O2 levels returned to baseline during intermittent wakefulness. Gas exchange patterns during sleep may contribute to the morbidity of sickle cell disease.

(JAMA 1983;249:1753-1755)