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January 18, 1995

Children as Research Subjects: Science, Ethics, and Law

Author Affiliations

University of South Florida Tampa

JAMA. 1995;273(3):258. doi:10.1001/jama.1995.03520270094049

The subject of research involving children is inherently one of contrast. The needs of society are balanced against the rights of the never competent individual. The possible good for many is weighed against the possible harm to one. Parents are asked to consent to their child's undergoing a research protocol as part of treatment by investigators with research projects who may also be parents. Children as Research Subjects, edited by Michael A. Grodin and Leonard H. Glantz, examines the topic of research involving children from these many varied perspectives. The editors have brought together a number of experienced individuals in an attempt to achieve a balanced examination of these complex issues.

The volume starts with a historical view of research using children as subjects. This first chapter should be read by all who involve children as research subjects or who have oversight responsibilities for such research. The remainder of the

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