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February 8, 1995

Tourette's SyndromeA Model Neuropsychiatric Disorder

Author Affiliations

From the Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Neuroscience Center at St Elizabeths Hospital, Washington, DC.

JAMA. 1995;273(6):498-501. doi:10.1001/jama.1995.03520300072040

CASE REPORT  Anthony and Brian (not their real names) are monozygotic (MZ) twins who were born by normal spontaneous vaginal delivery at full term following an unremarkable pregnancy. Labor lasted 3 hours, with Brian born by breech delivery 8 minutes after Anthony, who was born head first. Both twins were healthy at birth, Brian weighing 3000 g and Anthony 3254 g. Their neurodevelopmental milestones were normal and neither had learning disabilities or problems with hyperactivity, anxiety, phobias, or memory. From about 2 years of age, Brian was felt to be easily distracted and his gross motor skills also appeared to be less refined.Brian developed motor tics at age 6 years with eye blinking as the presenting symptom, and vocal tics began with sniffing at age 9 years. Anthony developed motor tics at age 7 years with eye blinking as the presenting symptom. He has never manifested vocal tics. The

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