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Article
August 26, 1983

The Human T-Cell Leukemia-Lymphoma Virus in the Southeastern United States

Author Affiliations

From the Environmental Epidemiology Branch (Drs Blayney and Blattner), the Laboratory of Tumor Cell Biology (Drs Robert-Guroff and Gallo), the Laboratory of Pathology (Dr Jaffe), the Medicine Branch (Dr Fisher), and the NCI-Navy Medical Oncology Branch (Dr Bunn), National Cancer Institute, Bethesda, Md; the Richmond County Health Department, Augusta, Ga (Dr Patton); and the Department of Health and Rehabilitative Services, Jacksonville, Fla (Dr Rarick).

JAMA. 1983;250(8):1048-1052. doi:10.1001/jama.1983.03340080026022
Abstract

The human T-cell leukemia-lymphoma virus (HTLV) is a recently described RNA tumor virus associated with human T-cell malignant neoplasms. In two geographic areas, Japan and the Caribbean basin, clusters of adult T-cell leukemia-lymphoma are "sentinel diseases" and have suggested an underlying prevalence of HTLV infection in both family members of the index cases and in the population. Four cases of lymphoma from the United States are described as illustrative of the sentinel disease. Serological studies of families and of a small population sample suggest that HTLV infection is endemic in certain parts of the southeastern United States at rates similar to those seen in Caribbean blacks but at a lower rate than that observed in southwestern Japan.

(JAMA 1983;250:1048-1052)

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