Membranous glomerulopathy and proteinuria have occurred in patients receiving captopril for hypertension. In this case of captopril-associated nephrotic syndrome, a pretreatment biopsy specimen showed normal histologic appearance and glomerular ultrastructure. A posttreatment biopsy specimen showed membranous glomerulopathy. It seems likely that captopril caused the membranous glomerulopathy.
Sturgill BC, Shearlock KT. Membranous Glomerulopathy and Nephrotic Syndrome After Captopril Therapy. JAMA. 1983;250(17):2343-2345. doi:10.1001/jama.1983.03340170069032