For patients, loss of vision is one of the most feared consequences of ophthalmic or systemic disease. For many, it is second only to death. Basic science and clinical research by visual scientists and ophthalmologists is steadily yielding the means to better prevent, diagnose, and treat diseases that cause blindness and erode our patients' quality of life.
Age-related macular degeneration is the leading cause of irreversible blindness in those older than 65 years in the United States, and treatment options are limited in the majority of cases. The pathophysiology involves degenerative changes in the macula or central retina. Recent interest has focused on the role of light-mediated free radical production and subsequent lipid peroxidation mediating damage in this area and, conversely, the role of food and dietary supplements that may block macular degeneration by scavenging free radicals and inhibiting these oxidative processes. The Eye Disease Case-Control Study Group analyzed 356
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