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June 14, 1995

Skin Reactions to Topical Aminophylline-Reply

Author Affiliations

Beverly Hills, Calif

JAMA. 1995;273(22):1738. doi:10.1001/jama.1995.03520460019019

In Reply.  —In response to Drs Simon and Terzian, I would like to make the following comments:To date, approximately 100 women have been studied in controlled trials designed to study the effect of aminophylline topically applied to the thighs. Of these women, only a few (described herein) have demonstrated any skin reactions to this treatment. These reactions were of minor severity and resolved spontaneously when the aminophylline application was stopped.The highest aminophylline concentration we studied was 10%. In one acute study, 51 subjects received a single application of 10% aminophylline in Aquaphor ointment system. Patch tests were conducted, and the results indicated a negative response for all subjects after 24 hours and 48 hours, except for one subject that experienced a mild (1+) response after 48 hours. In a second study, 34 women were treated five times per week with this 10% aminophylline ointment for a period of

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