In 76 smokers, correlations between plasma nicotine and alveolar carbon monoxide levels of the individual smoker and the nicotine and CO yields of his cigarette were very poor. In 24 smokers of low-nicotine, low-tar cigarettes, mean alveolar CO levels did not differ from those of smokers of regular cigarettes. Mean plasma nicotine levels were lower in smokers of low-nicotine cigarettes, but a wide overlap of individual values occurred. The implication that an individual shifting to ultra-low-tar cigarettes reduces risks of cardiopulmonary disease is unwarranted.
Ebert RV, McNabb ME, McCusker KT, Snow SL. Amount of Nicotine and Carbon Monoxide Inhaled by Smokers of Low-Tar, Low-Nicotine Cigarettes. JAMA. 1983;250(20):2840-2842. doi:10.1001/jama.1983.03340200074034