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June 28, 1995

False-positive Benzodiazepine Urine Test Due to Oxaprozin-Reply

Author Affiliations

GD Searle & Co Skokie, Ill

JAMA. 1995;273(24):1905-1906. doi:10.1001/jama.1995.03520480023026

In Reply.  —We thank Dr Pulini for her interest in this issue. Laboratory test interferences have been reported by Jelic-Ivanovic et al1 and in the complete prescribing information for several NSAIDs, including etodolac (Lodine, Wyeth-Ayerst Laboratories, Philadelphia, Pa), naproxen sodium (Anaprox, Naprosyn; Syntex Puerto Rico Inc), fenoprofen calcium (Nalfon, Eli Lilly and Co, Indianapolis, Ind), and tolmetin sodium (Tolectin, McNeil Pharmaceuticals, Raritan, NJ), and GD Searle & Co has received reports of alleged false-positive benzodiazepine test results from standard urine toxicology screens for drugs of abuse in patients taking oxaprozin. Based on our investigation into this matter, the prescribing information for oxaprozin was updated in November 1993 to reflect the new information. The 1994 Physicians' Desk Reference (PDR) had already gone to press at that time; current information appears in the 1995 PDR and in the PDR on CD-ROM.2Although oxaprozin is not chemically related to the benzodiazepines,

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