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July 5, 1995

Treatment of Acute Cystitis-Reply

Author Affiliations

Harborview Madison Clinic Seattle, Wash

JAMA. 1995;274(1):26. doi:10.1001/jama.1995.03530010039028

In Reply.  —The subjects in our trial were university students with an age range of 18 to 42 years, which was similar in each of the four treatment groups. We evaluated the effect of diaphragm use as the contraceptive method at enrollment and noted in the text that treatment outcome did not appear to be associated with diaphragm use. Although the numbers were small, women who used diaphragms generally had better outcome among all treatment groups, except for those treated with nitrofurantoin. Thus, among diaphragm users compared with nonusers, the cure rates were as follows: 100% (4/4) vs 80% (28/35) in the trimethoprim-sulfamethoxazole group; 50% (4/8) vs 64% (18/28) in the nitrofurantoin group; 100% (7/7) vs 56% (14/25) in the cefadroxil group; and 80% (4/5) vs 65% (24/37) in the amoxicillin group. Nitrofurantoin performed poorly regardless of diaphragm use. The sexual activity of subjects was not assessed during or after

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