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July 26, 1995

Sydenham's Chorea-Reply

Author Affiliations

National Institute of Mental Health Bethesda, Md

JAMA. 1995;274(4):304. doi:10.1001/jama.1995.03530040030034

In Reply.  —Because of the potential for controversy about the utility of Sydenham's chorea as an etiologic model for childhood-onset obsessive-compulsive disorder and Gilles de la Tourette's syndrome, I was surprised and pleased that the concerns raised did not address this issue, but rather the details of the case report. I appreciate the careful consideration given to the article by Dr Jeret and Dr Jaffe, and I also appreciate the opportunity to clarify the Grand Rounds presentation.As pointed out by Jeret, the EEG findings in the case report were condensed in a confusing fashion. The pertinent portion of the original EEG report reads as follows: "mildly abnormal and consistent with Sydenham's chorea" because of the presence (during wakefulness) of "a background consisting of an irregular rhythm bilaterally which has a maximum frequency of 9 Hz; intermixed, there are many slow waves of 4-5 Hz frequency and 20-40 microvolts in

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