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August 23, 1995

Ischemic Optic Neuropathy Decompression Trial

Author Affiliations

Englewood, Colo

JAMA. 1995;274(8):612. doi:10.1001/jama.1995.03530080028032

To the Editor.  —Regarding the publication by the Ischemic Optic Neuropathy Decompression Trial (IONDT) Research Group,1 it seems noteworthy that 72% of the surgically treated patients in this trial were treated more than a week after onset of symptoms. No one was treated within the first 24 hours. Given that the window of opportunity for treatment of acute ischemic cerebrovascular disease is probably 6 hours or less, one wonders whether the treatment is truly ineffective or whether it was simply applied much too late.

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