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September 13, 1995

Long-term Survival Following Bacteremia or Fungemia

Author Affiliations

From the Department of Medicine B (Dr Leibovici), the Microbiology Laboratory (Dr Samra), and the Infectious Diseases Unit (Ms Konigsberger and Drs Drucker, Ashkenazi, and Pitlik), Beilinson Medical Center, Petah Tiqva, Israel; and the Sackler Faculty of Medicine, University of Tel Aviv, Ramat Aviv, Israel (Drs Leibovici, Samra, Drucker, Ashkenazi, and Pitlik and Ms Konigsberger).

JAMA. 1995;274(10):807-812. doi:10.1001/jama.1995.03530100047033

Objective.  —To delineate long-term survival after an episode of bacteremia or fungemia and risk factors for mortality.

Design.  —Cohort study.

Setting.  —A 900-bed university hospital in Israel.

Patients.  —Study group comprising 1991 patients 18 years of age or older in whom bacteremia or fungemia were detected between March 1988 and October 1992, and a control group comprising 1991 inpatients without any infectious diseases, matched for age, sex, department, date of admission, and underlying disorders.

Interventions.  —None.

Measurements.  —Interval from the date of the first positive blood culture (study group) or from date of the identical hospital day (in the matched control patient) to the date of death as recorded in the Israeli National Population registry or, if alive, to June 1, 1994.

Results.  —The median age of patients was 72 years. In the study group, the mortality rate was 26% at 1 month, 43% at 6 months, 48% at 1 year, and 63% at 4 years, and the median survival was 16.2 months. In the control group, the mortality rate was 7% at 1 month, 27% at 1 year, and 42% at 4 years, and the median survival was greater than 75 months (P<.001). Factors significantly and independently associated with mortality in bacteremic patients were functional class (median survival, 0.5 month in bedridden patients), septic shock (median survival, 0.2 month), serum albumin (median survival, 1.1 months in the lowest quartile), serum creatinine (median survival, 2.9 months in the highest quartile), age (median survival, 2.9 months in the highest quartile [age >80 years]), inappropriate empirical antibiotic treatment (median survival, 4.9 months), nosocomial infection (median survival, 9.6 months), and malignancy (median survival, 2.4 months).

Conclusions.  —Bacteremia is associated with high short-term mortality, but also a sign of severely curtailed long-term prognosis, especially in patients with low functional capacity, low serum albumin, high serum creatinine, nosocomial infections, malignancy, inappropriate antimicrobial treatment, and septic shock and in elderly patients.(JAMA. 1995;274:807-812)