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November 1, 1995

Three vs 10 Days of Trimethoprim/Sulfamethoxazole for Acute Maxillary Sinusitis

Author Affiliations

Abbott Northwestern Hospital Minneapolis, Minn

JAMA. 1995;274(17):1341. doi:10.1001/jama.1995.03530170021010

To the Editor.  —Dr Williams and colleagues1 compare two treatments for sinusitis and conclude that one is as good as the other. These negative results might be important if the study had the necessary statistical power. We are not told this, but assume that a comparison of two groups each having just 40 patients is probably inconclusive if no statistically significant difference is shown. Furthermore, since, as pointed out by the authors, another study2 showed in 71% of patients a clinical response to a decongestant alone, one would have liked to see a comparison of the two antibiotic treatment groups with a third group not treated with antibiotics. As it stands now, the help from this study is rather limited.

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