July 19, 1971

Nitroglycerin Tablets Loss of Potency-Reply

Author Affiliations

Bethesda, Md

JAMA. 1971;217(3):340. doi:10.1001/jama.1971.03190030064019

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To the Editor.—  Nitroglycerin tablets are recognized in the United States Pharmacopeia. As such, they are required by the federal and state food and drug acts to be packaged in accordance with the requirements contained therein. Contrary to a common belief, this requirement is applicable not only to manufacturers but to dispensers of the drug. USP XVIII requires that nitroglycerin tablets be packaged in tight containers. Page 9 of the Pharmacopeia defines a tight container as one which protects the contents from contamination by extraneous liquids, solids, or vapors, from loss of the drug, and from efflorescence, deliquescence, or evaporation under the ordinary or customary conditions of handling, shipment, storage, and distribution, and is capable of tight re-closure.A USP Pharmacy Board Bulletin dated March 17, 1971, specifically notified pharmacy board members of this requirement and recommended that patients be warned not to transfer the prescription medication to other containers.