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July 19, 1971

Thiabendazole Effects in Visceral Larva Migrans

Author Affiliations

Rahway, NJ

JAMA. 1971;217(3):342-343. doi:10.1001/jama.1971.03190030066027

To the Editor.—  It has been postulated that antiinflammatory, antipyretic, and analgesic effects may contribute to the clinical response that is often observed in the treatment of trichinosis with thiabendazole.1 These nonspecific pharmacologic effects, thus far demonstrated only in laboratory animals, may also contribute to the clinical response seen in the treatment of certain other helminth and mycotic infections.In several cases of visceral larva migrans, thiabendazole treatment was followed promptly by an amelioration of symptoms, including the reduction of fever.2-4 In one of these cases,2 the response was characterized by defervescence with recurrence of fever on two occasions when treatment was interrupted, and defervescence when treatment was resumed. This response may have been due to a subcurative anthelmintic action; but, it could also be explained partially or even totally on the basis of nonspecific effects. In other cases,3 treatment was followed by prompt alleviation of