Reye's syndrome has been infrequently described in children receiving long-term salicylate therapy. We report the clinical and laboratory findings of two children in whom Reye's syndrome developed while taking salicylates for systemic inflammatory disorders. Monitoring of hepatocellular function should be considered in children who are receiving long-term salicylate therapy.
Young RSK, Torretti D, Williams RH, Hendriksen D, Woods M. Reye's Syndrome Associated With Long-term Aspirin Therapy. JAMA. 1984;251(6):754–756. doi:10.1001/jama.1984.03340300046027