The newly available antihistamine astemizole (Hismanal) has been previously associated with hemodynamically significant cardiac tachydysrhythmias. We describe a 3-year-old girl who developed multiple different cardiac dysrhythmias after an astemizole overdose. No hemodynamic compromise occurred, and the electrocardiogram returned to normal without use of antiarrhythmic agents within 7 hours.
Tobin JR, Doyle TP, Ackerman AD, Brenner JI. Astemizole-Induced Cardiac Conduction Disturbances in a Child. JAMA. 1991;266(19):2737-2740. doi:10.1001/jama.1991.03470190085034