To the Editor.
— Kaposi's sarcoma (KS) occurring in patients with the acquired immunodeficiency syndrome (AIDS) follows an aggressive clinical course. It frequently involves cutaneous and extracutaneous sites.1 Prognosis bears a strong relationship to extent of disease, concomitant opportunistic infections, and ratio of helper and suppressor T cells.2 Radiation therapy is often used for palliation of symptomatic lesions or to improve cosmesis.As a referral center for the treatment of KS, the Radiation Center of The New York Hospital-Cornell Medical Center has treated 219 patients with irradiation from September 1986 to June 1991. Eighty-six patients had involvement of the lower extremities and 58 of them had lower extremity lymphedema; eight of these patients died of suspected pulmonary thromboembolism. All had extensive involvement of a lower extremity with KS, lymphedema, and sudden onset of calf pain. Distal pulses were absent. Acute onset of chest pain and shortness of breath
Kaufmann T, Nisce LZ, Metroka C. Thromboembolism in AIDS-Related Kaposi's Sarcoma. JAMA. 1991;266(20):2834. doi:10.1001/jama.1991.03470200046030