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November 27, 1991

Cholesterol and Atherosclerosis: Diagnosis and Treatment

Author Affiliations

University of Rochester (NY) School of Medicine and Dentistry

University of Rochester (NY) School of Medicine and Dentistry

JAMA. 1991;266(20):2910-2911. doi:10.1001/jama.1991.03470200124052

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This single-authored, colorfully illustrated book provides an excellent written and visual presentation of the complex biochemical and physiological pathways of lipoprotein metabolism. The book meets the primary goal of the author—to show how abnormalities in lipoprotein metabolism relate to the development of various dyslipidemias and clinical atherosclerosis.

The first of four major units covers cholesterol, atherosclerosis, and coronary heart disease, including cholesterol and lipoprotein metabolism and transport, the steps in atherogenesis, and the evidence supporting the cholesterol— coronary disease relationship. The unit on classification of lipid disorders is more clinically oriented and provides a useful outline of causes of genetic and acquired hypercholesterolemia.

The approach to dietary therapy for hyperlipidemia is rational, buttressed by graphic presentation of appropriate mechanistic metabolic pathways. Finally, indications and practical recommendations for drug therapy for hyperlipidemia are given.

Information is accumulating rapidly about cholesterol and fatty acid transport; the origin and role of very low—density