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August 3, 1984

Jamshedpur Fever and Reye's Syndrome

Author Affiliations

The Children's Mercy Hospital Kansas City, Mo

JAMA. 1984;252(5):627. doi:10.1001/jama.1984.03350050019013

To the Editor.—  The additional details of Jamshedpur fever provided by Dr Khan1 are of interest. Contrary to Dr Khan's impression, however, the identity of Jamshedpur fever with Reye's syndrome has previously been discussed. When we first reported the epidemic occurrence of Reye's syndrome in northeastern Thailand, we listed Jamshedpur fever as one of other syndromes of encephalopathy and fatty degeneration of the viscera.2 The source of our information was from personal correspondence with T. Jacob John of the Christian Medical College in Vellore (September 1969) and the report of John et al3 from that institution of three cases of Reye's syndrome. Dr John and his colleagues noted the similarity of their cases and those of Jamshedpur fever and cited Dr Khan's article as well as Chari and Swamy's4 publication on the subject.Subsequent investigations in Thailand convinced us that aflatoxin was the etiologic agent of the