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Article
December 18, 1991

Carotid Endarterectomy and Prevention of Cerebral Ischemia in Symptomatic Carotid Stenosis

Marc R. Mayberg, MD; S. Eric Wilson, MD; Frank Yatsu, MD; et al David G. Weiss, PhD; Louis Messina, MD; Linda A. Hershey, MD; Cindy Colling, RPh; Joseph Eskridge, MD; Daniel Deykin, MD; H. Richard Winn, MD; Phillip Kistler, MD; P.J. Mohr, MD; Hermes Kontos, MD; Mimi Platt; Calvin Ernst, MD; Lawrence Wechsler, MD; Elmer Hall, PhD; Martin Weiss, MD; Rose Kurz; Edgard Perez; Daniel Safer, MD; Rev Maurice Moore; Thomas Hobbins, MD; Megan Arthur; Allen Raskin, PhD; Rep Martin Feldbush, (D, Minn); Mike Lee, MS; Diana Preston; Debbie Davis; Linda Dunford; Cathy Lucas; John Bergan, MD; Ralph G. Dacey Jr, MD; James Grotta, MD; Henry J. M. Barnett, MD; Roberto Heros, MD; J. P. Mohr, MD; Wesley S. Moore, MD; Janet Gold; Ping Huang, PhD; David Fink, MD; Marc Chimowitz, MD; John McGillicuddy, MD; Susan Grube, RN; Eva Morgenstern, MD; Stephen Rerych, MD; Cindy McCutcheon, RN; John Ammons, MD; Robert Smith, MD; Rita Giannetti, RN; Willard Johnson, MD; Viken Babikian, MD; Joel Abramovitz, MD; Nancy Allen, RN; Linda Hershey, MD; Irineo Gutierrez, MD; Virginia Corbett, RN; Joan Barren, RN; Frank Padberg Jr., MD; Said Shanawani, MD; Carolyn Rogers, RN; Stephen Reid, MD; Steven Nadeau, MD; James Seeger, MD; Randi Baum, MHS; Fred Littooy, MD; Sudha Gupta, MD; John Maggio, PhD; Stephen Lalka, MD; R. V. Reddy, MD; Marinel Kriese, RN; Charles Acher, MD; Ross Levine, MD; Judy Archibald, RN; Dale Strawn, MD; Michael Remler, MD; Debi Calogero; William Lawrence, MD; Ismar Cintera, MD; Michaela Hall, RN; Dick Jones, RN; Michel Makaroun, MD; Julie Thompson, DO; Amin Faris, MD; John Moossv, MD; Stacy Love, RN; Pat Lyden, MD; Robert Hye, MD; Rod Lamond, MD; Traci Babcock, RN; Geraldine Cali, RN; Thomas Bird, MD; Frank Emmons, MD; Nancy Ploch, RN; Stan Cohen, MD; Russell Williams, MD; John Frazee, MD; Martin Josephson, MD; Cathy Hubbert, RNC
Author Affiliations

Planning Committee; Boston, Mass; New York, NY; Richmond, Va; Seattle, Wash; Executive Committee; Study Administrative Coordinator; Data Monitoring Board; Detroit, Mich.; Pittsburgh, Pa; Atlanta, Ga; Los Angeles, Calif; Human Rights Committee (Baltimore, Md); VA Cooperative Studies Coordinating Center, Perry Point, Md; Central Radiologist; Clinical Research Pharmacist; Adjudication Committee; San Diego, Calif; St Louis, Mo; Houston, Tex; End Point Definition Committee; London, Ontario; San Diego, Calif; Minneapolis, Minn; New York, NY; Los Angeles, Calif; VA Cooperative Studies Program; chief (Boston, Mass); administrative officer (Boston); staff assistant (Washington, DC); Principal Investigators/Study Technicians: Ann Arbor, Mich, VAMC; Asheville, NC, VAMC; Atlanta, Ga, VAMC; Boston (Jamaica Plain), Mass, VAMC; Buffalo, NY, VAMC; East Orange, NJ, VAMC; Gainesville, Fla, VAMC; Hines (Chicago, Ill) VAMC; Indianapolis, Ind, VAMC; Madison, Wis, VAMC; Martinez, Calif, VAMC; Phoenix, Ariz, VAMC; Pittsburgh, Pa, VAMC; San Diego, Calif, VAMC; Seattle, Wash, VAMC; Los Angeles (Wadsworth), Calif, VAMC;
From the Departments of Neurological Surgery (Drs Mayberg and Winn) and Radiology (Dr Eskridge), University of Washington and Seattle Veterans Affairs Medical Center; the Department of Surgery, Harbor UCLA Medical Center and Wadsworth Veterans Affairs Medical Center, Los Angeles, Calif (Dr Wilson); the Department of Neurology, University of Texas Medical School, Houston (Dr Yatsu); the Department of Veterans Affairs Cooperative Studies Program Coordinating Center, Perry Point, Md (Dr Weiss); the Department of Vascular Surgery, University of Michigan and Ann Arbor Veterans Affairs Medical Center (Dr Messina); the Department of Neurology, State University of New York at Buffalo and Buffalo Veterans Affairs Medical Center (Dr Hershey); the Clinical Research Pharmacy, Department of Veterans Affairs Cooperative Studies Program, Albuquerque, NM (Ms Colling); and the Department of Veterans Affairs Cooperative Studies Program, Boston, Mass (Dr Deykin).

Planning Committee; Boston, Mass; New York, NY; Richmond, Va; Seattle, Wash; Executive Committee; Study Administrative Coordinator; Data Monitoring Board; Detroit, Mich.; Pittsburgh, Pa; Atlanta, Ga; Los Angeles, Calif; Human Rights Committee (Baltimore, Md); VA Cooperative Studies Coordinating Center, Perry Point, Md; Central Radiologist; Clinical Research Pharmacist; Adjudication Committee; San Diego, Calif; St Louis, Mo; Houston, Tex; End Point Definition Committee; London, Ontario; San Diego, Calif; Minneapolis, Minn; New York, NY; Los Angeles, Calif; VA Cooperative Studies Program; chief (Boston, Mass); administrative officer (Boston); staff assistant (Washington, DC); Principal Investigators/Study Technicians: Ann Arbor, Mich, VAMC; Asheville, NC, VAMC; Atlanta, Ga, VAMC; Boston (Jamaica Plain), Mass, VAMC; Buffalo, NY, VAMC; East Orange, NJ, VAMC; Gainesville, Fla, VAMC; Hines (Chicago, Ill) VAMC; Indianapolis, Ind, VAMC; Madison, Wis, VAMC; Martinez, Calif, VAMC; Phoenix, Ariz, VAMC; Pittsburgh, Pa, VAMC; San Diego, Calif, VAMC; Seattle, Wash, VAMC; Los Angeles (Wadsworth), Calif, VAMC;
From the Departments of Neurological Surgery (Drs Mayberg and Winn) and Radiology (Dr Eskridge), University of Washington and Seattle Veterans Affairs Medical Center; the Department of Surgery, Harbor UCLA Medical Center and Wadsworth Veterans Affairs Medical Center, Los Angeles, Calif (Dr Wilson); the Department of Neurology, University of Texas Medical School, Houston (Dr Yatsu); the Department of Veterans Affairs Cooperative Studies Program Coordinating Center, Perry Point, Md (Dr Weiss); the Department of Vascular Surgery, University of Michigan and Ann Arbor Veterans Affairs Medical Center (Dr Messina); the Department of Neurology, State University of New York at Buffalo and Buffalo Veterans Affairs Medical Center (Dr Hershey); the Clinical Research Pharmacy, Department of Veterans Affairs Cooperative Studies Program, Albuquerque, NM (Ms Colling); and the Department of Veterans Affairs Cooperative Studies Program, Boston, Mass (Dr Deykin).

JAMA. 1991;266(23):3289-3294. doi:10.1001/jama.1991.03470230047029
Abstract

Objective.  —To determine whether carotid endarterectomy provides protection against subsequent cerebral ischemia in men with ischemic symptoms in the distribution of significant (>50%) ipsilateral internal carotid artery stenosis.

Design.  —Prospective, randomized, multicenter trial.

Setting.  —Sixteen university-affiliated Veterans Affairs medical centers.

Patients.  —Men who presented within 120 days of onset of symptoms that were consistent with transient ischemic attacks, transient monocular blindness, or recent small completed strokes between July 1988 and February 1991. Among 5000 patients screened, 189 individuals were randomized with angiographic internal carotid artery stenosis greater than 50% ipsilateral to the presenting symptoms. Forty-eight eligible patients who refused entry were followed up outside of the trial.

Outcome Measures.  —Cerebral infarction or crescendo transient ischemic attacks in the vascular distribution of the original symptoms or death within 30 days of randomization.

Intervention.  —Carotid endarterectomy plus the best medical care (n = 91) vs the best medical care alone (n=98).

Results.  —At a mean follow-up of 11.9 months, there was a significant reduction in stroke or crescendo transient ischemic attacks in patients who received carotid endarterectomy (7.7%) compared with nonsurgical patients (19.4%), or an absolute risk reduction of 11.7% (P=.011). The benefit of surgery was more profound in patients with internal carotid artery stenosis greater than 70% (absolute risk reduction, 17.7%; P =.004). The benefit of surgery was apparent within 2 months after randomization, and only one stroke was noted in the surgical group beyond the 30-day perioperative period.

Conclusions.  —For a selected cohort of men with symptoms of cerebral or retinal ischemia in the distribution of a high-grade internal carotid artery stenosis, carotid endarterectomy can effectively reduce the risk of subsequent ipsilateral cerebral ischemia. The risk of cerebral ischemia in this subgroup of patients is considerably higher than previously estimated.(JAMA. 1991;266:3289-3294)

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