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January 1, 1992

Group A Streptococcus Septicemia in Children-Reply

Author Affiliations

The Children's Hospital Denver, Colo

JAMA. 1992;267(1):53. doi:10.1001/jama.1992.03480010061014

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In Reply.  —There are several ways to demonstrate a real increase in group A streptococcal sepsis in children based on data from our article. We demonstrated a significant increase in group A streptococcal bacteremia from 1980 through 1990 based on a comparison of cases per 10 000 discharges. At the same time, the rate of Haemophilus influenzae bacteremia went down, and the rate of Streptococcus pneumoniae was unchanged. Dr Hexter suggests several other relevant comparisons. Because the 1980 through 1982 data on the average lengths of stay were not easily accessible, comparison of the periods 1983 through 1984 and 1989 through 1990 was made.In order to control for lengths of stay, the incidence density for positive blood cultures for 1983 through 1984 was calculated to be 0.007 positive cultures per patient-day, whereas the 1989 through 1990 data indicated a rate of 0.008. The intensity of discovery as it relates