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It has been 25 years since the first edition of this work, and the fact that it thrives indicates that it has been useful to many practitioners. Its objective has not changed: "to bring together in concise, definitive articles the best current information on medical diagnosis to assist the physician in arriving at the correct diagnosis as efficiently as possible."
A section addressing 29 common diagnostic problems is followed by 16 sections on categories of disease and a final section that tabulates laboratory values of clinical importance. There are about 300 chapters, most three to seven pages in length, each written by one to four expert practitioners. Most chapters are by newly recruited authors. Formerly popular diagnostic methods that have been superseded and pitfalls of diagnosis are mentioned where appropriate. Diagnostic imaging has become increasingly important. Some topics of new or increased emphasis are the acquired immunodeficiency syndrome, toxic shock
Best WR, Hines E. Current Diagnosis 8. JAMA. 1992;267(2):298–299. doi:10.1001/jama.1992.03480020108043