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January 15, 1992

Aspirin Use and Cardiovascular Disease in Women

Author Affiliations

Boston (Mass) University School of Medicine
Framingham (Mass) Heart Study

JAMA. 1992;267(3):364-365. doi:10.1001/jama.1992.03480030042024

To the Editor.  —In their recent article, Manson et al1 reported a reduced risk of myocardial infarction (MI) in women who took one through six aspirin per week. An analysis of data from the Framingham Heart Study suggests a similar effect in older men and women for cardiovascular disease (CVD) and cerebrovascular disease, including transient ischemic attacks.

Study.  —At biennial examination 17 in 1981 to 1983, the examining physician recorded the number of aspirin taken per week. Of the 508 men and 917 women aged 63 through 94 years who were free of CVD and who were followed up through examination 19, there were 17% who reported taking one through six aspirin per week, 12% reported taking seven or more aspirin per week, and 71% reported taking no aspirin. Information on the indications for aspirin use was not collected. By the end of examination 19 (4 years