—To determine the relative frequencies of primary and reactivation tuberculosis in the urban homeless.
—Prospective evaluation of homeless tuberculosis patients.
—Central Los Angeles, Calif.
—Thirty-four homeless patients with culture-proven tuberculosis.
—IS61 10-based restriction fragment length polymorphism (RFLP) analysis was performed on Mycobacterium tuberculosis isolates. If results were inconclusive, pTBN12-based RFLP analysis was performed.
Main Outcome Measure.
—Clustering of M tuberculosis isolates. A cluster consisted of two or more isolates with indistinguishable RFLP patterns.
—Twenty-four of 34 homeless patients had clustered isolates in six clusters.
—The minimum percentage of cases due to primary tuberculosis in the homeless was estimated to be 53%, compared with the traditional estimate of 10% in the general population. The results suggest that primary tuberculosis caused the majority of tuberculosis cases in this population of the urban homeless in central Los Angeles.(JAMA. 1996;275:305-307)
Barnes PF, El-Hajj H, Preston-Martin S, Cave MD, Jones BE, Otaya M, Pogoda J, Eisenach KD. Transmission of Tuberculosis Among the Urban Homeless. JAMA. 1996;275(4):305-307. doi:10.1001/jama.1996.03530280057037