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January 24, 1996

The Search for an AIDS Vaccine: Ethical Issues in the Development and Testing of a Preventive HIV Vaccine

Author Affiliations

University of California, San Francisco

JAMA. 1996;275(4):329. doi:10.1001/jama.1996.03530280081049

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Increasingly, medical and public attention has focused on the potential efficacy of vaccines to prevent HIV infection. This is no surprise: there have been approximately 17 million HIV infections in the world to date, existing treatments for HIV infection have only limited efficacy, and the great majority of the HIV-infected population has essentially no access to even these medications. While biomedical advances in vaccine development are frequently trumpeted in the media, often out of proportion to the substance of the actual accomplishments, debates over the no less contentious ethical and social aspects of HIV-vaccine trials usually remain hidden from public view. It is this imbalance that Dr Christine Grady, successfully, seeks to right.

The Search for an AIDS Vaccine is an ambitious work. The first two chapters are devoted to reviewing the history of vaccines, explaining the vaccine development and regulatory processes, and summarizing the major developments in the burgeoning