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April 8, 1992

Radiation Therapy in Patients With AIDS-Related Central Nervous System Lymphomas

Author Affiliations

The New York Hospital—Cornell Medical Center
Columbia University of Physicians and Surgeons New York

JAMA. 1992;267(14):1921-1922. doi:10.1001/jama.1992.03480140047026

To the Editor.  —Recently, there were three reports in JAMA1-3 regarding central nervous system prophylaxis of patients with acquired immunodeficiency syndrome (AIDS)—related non-Hodgkin's lymphoma (NHL). This has prompted us to report our experience in the treatment of similar patients.From June 1987 to December 1991, the Radiation Oncology Center at The New York Hospital—Cornell Medical Center has used brain irradiation to treat 25 men with AIDS-related central nervous system NHL. Ages ranged from 27 to 57 years (median, 37.8 years). All patients except one had a history of opportunistic infections. Virtually all were receiving antiretroviral therapy. Twenty-one had primary brain lymphoma, four had central nervous system relapse of NHL, and three of them had received combination chemotherapy. Two patients had associated Kaposi's sarcoma.All patients had clinical neurological deficits, and computed transverse tomography (CT) and/or magnetic resonance imaging (MRI) were highly suggestive of lymphoma. Six had positive brain biopsy